M.D., Ph.D. from Paris University, 57 year old, married, 1 child. Teyton arrived in the USA in 1987 for a post-doctoral fellowship at the Scripps Research Institute. TSRI staff member since 1991. His laboratory has been at the forefront of antigen presentation by discovering the double role of the invariant chain (1990), elucidating the first structure of an I-A MHC class II molecule (1998). This knowledge has been applied to studying autoimmunity and determining the first structure of a diabetogenic MHC molecule (2000) and the first TCR/MHC complex structure relevant to the understanding of immune diabetes (2010). In addition, studies aimed at understanding T cell activation led to the first structure of a T cell receptor (1996) and the first structure of a pMHC/TCR complex (1998). Finally, a third focus of the laboratory has been the studying of lipid transport and recognition by immune cells. This work has allowed the discovery of the role of saposins in immunity (2004), the elucidation of the role of NKT cells in antigen priming, the first 2 structures of CD1-lipid complexes (2002), the discovery of the first endogenous ligand of NKT cells (2003) and the role of serum transport for antigen recognition (2010). More recent work includes the description of a-linked glycosylceramides as natural endogenous ligands of NKT cells (2016). A strong emphasis of Teyton's laboratory is to translate basic knowledge to human immunology.