T cell antigen receptor signaling and iNKT cell development

T cell antigen receptor signaling and iNKT cell development

T cell antigen receptor signaling and iNKT cell development (#3)

Laurent Gapin ¹

University of Colorado, Aurora, CO, United States

Recent experiments demonstrated that iNKT cells can develop into functionally distinct subsets and that the relative abundance of the various subsets is directly responsible for altering several immunological parameters, such as the development of “conventional” CD8 T cells as well as the secretion of chemokines by dendritic cells. However, the signals involved in determining the developmental fate of iNKT cell precursors remain incompletely understood. Using high-dimensional flow-cytometry analysis to delineate iNKT cell development, we establish a function for the T-cell receptor signaling machinery in influencing the development of the various iNKT cell subsets.

Authors contributing to this presentation.

Gapin, L

I have a broad background in immunology/biochemistry, with specific training and expertise in iNKT cells, T cell development and MHC/antigen/TCR interactions. As a postdoctoral fellow at the La Jolla institute for Allergy and Immunology with Dr. Mitchell Kronenberg, I carried out several projects related to the biology of iNKT cells (development, TCR repertoire, cytokine secretion, homeostasis). As PI with NIH-funded grants, I continued to study several aspects of iNKT cell biology. During the past few years, we have been interested in understanding how the iNKT TCR recognize lipid antigens presented by CD1d molecules and how this recognition influences the formation of the iNKT cell repertoire.

T cell antigen receptor signaling and iNKT cell development (#3)

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Gapin, L

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