How the transcription factor PLZF directs acquisition of innate effector programs

How the transcription factor PLZF directs acquisition of innate effector programs

How the transcription factor PLZF directs acquisition of innate effector programs (#8)

Albert Bendelac ¹

The University of Chicago, Chicago, IL, United States

The transcription factor PLZF is critically involved in the development of NKT cells and other innate-like lineages including MAIT cells and some gd T subsets. PLZF is also essential during development of innate lymphocytes, particularly ILC2. Using biotinylation-based ChIP-seq, we identified the main targets of PLZF in NKT thymocytes and show that PLZF exerts direct and indirect effects on multiple effector genes. The results account for the developmental acquisition of effector programs in many innate and innate like populations.

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Bendelac, A

Albert Bendelac received his MD PhD from University of Paris VI and Paris VII. He is the A.N. Pritzker Professor at the University of Chicago and his primary interests reside in the biology of innate and innate-like lymphocytes. His laboratory has contributed to the characterization of several innate lineages, particularly NKT cells and ILCs, defining fundamental aspects of development, specificity and function, and creating widely used mouse models for studies in vivo.

How the transcription factor PLZF directs acquisition of innate effector programs (#8)

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Bendelac, A

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